All enrolled people who obtained at least one particular dose of zosuquidar or placebo throughout induction have been monitored for your incidence of adverse situations (439 patients, 219 on zosuquidar and 210 on placebo). The most common adverse functions ended up related to the duration of extended and significant myelosuppression as is anticipat
These trials confirmed clinically sizeable pharmacokinetic interactions [7] characterized by a reduce during the clearance from the anticancer drug and for this reason increased exposure. The interpretation of subsequent section II and III scientific trials was difficult because it was not possible to administer a similar dose of chemotherapy withi
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species, triggers rapid plant necrosis and chlorosis, much like that of bipyridinium herbicides like paraquat [63]. Research with isolated chloroplasts confirmed that its manner of action is precisely like bipyridiniums, diverting electrons from photosystem I to become reduced into a reactive radicle that subsequently generates superoxide radicle,
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